Primatologist Davis Okoye (Dwayne Johnson), a man who keeps people at a distance, shares an unshakable and unbreakable bond with George, the extraordinarily intelligent, albino gorilla who has been in his care most of its life. But a mysterious genetic experiment mutates this once gentle ape into a raging creature of enormous size. To make matters worse, it’s soon discovered that a wolf (Ralph) and crocodile (Lizzie) have gone under similar changes. As these newly created apex predators battle each other for supremacy and tear across North America, destroying everything in their path, Okoye teams with a discredited genetic engineer (Naomie Harris) to secure an antidote and fight his way through the ever-changing battlefield, not only to halt a global catastrophe, but also to save the fearsome beast that was once his friend.
